Tumor-derived ILT4 induces T cell senescence and suppresses tumor immunity
نویسندگان
چکیده
منابع مشابه
TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence
Accumulating evidence suggests the immunosuppressive microenvironments created by malignant tumors represent a major obstacle for effective anti-tumor immunity. A better understanding of the suppressive mechanisms mediated by tumor microenvironments and the development of strategies to reverse the immune suppression are major challenges for the success of tumor immunotherapy. Here, we report th...
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Splicing isoforms of certain genes impact on genetic biodiversity in mammals. The tumor suppressor TP53 gene plays an important role in the regulation of tumorigenesis in hepatocellular carcinoma (HCC). Delta40p53 (Δ40p53) is a naturally occurring p53 isoform that lacks Nterminal transactivation domain, yet little is known about the role of Δ40p53 in the development of HCC. Here, we first repor...
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Extramedullary myelopoiesis occurs commonly in tumor-bearing animals and is known to lead to accumulation of peripheral myeloid-derived suppressor cells (MDSC), which play an important role in immune escape. However, the cellular and molecular mechanisms by which tumors induce extramedullary myelopoiesis are poorly understood. In this study, we found that osteopontin expressed by tumor cells en...
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T cell immunity is critical for protection against infectious agents as well as cancer. T cell immune response is a well orchestrated process that involves three key components. CD8+ T cells that harbor cytolytic machinery and can target and kill the tumor cells in an antigen specific manner, CD4+ T cells that can either “help” the generation of a productive CD8+ T cell or “regulate/suppress” i...
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ژورنال
عنوان ژورنال: Journal for ImmunoTherapy of Cancer
سال: 2021
ISSN: 2051-1426
DOI: 10.1136/jitc-2020-001536